Author(s): Rana Samir Mohamed, Mahmoud Ahmed Kamal, Mohamed Mostafa Dabees, Khaled Kotb Abdallah Mohamed
Aim: To assess the effect of Intravitreal Injection (IVI) of Ranibizumab on Central Choroidal Thickness (CCT) using Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) and its correlation with Central Macular Thickness (CMT) and Best Corrected Visual Acuity (BCVA) in eyes with center involving diabetic macular edema.
Materials and methods: Prospective interventional study including 60 eyes with center involving diabetic macular edema which will receive three consecutive monthly IVI of Ranibizumab.
Results: Baseline CCT decreased from 256 µm-432 µm (Mean 322.1 ± 63.17 SD) to 227 µm-303 µm (Mean 271.6 ± 26.53 SD). Baseline CMT decreased from 401 µm-718 µm (Mean 526.45 ± 99.63 SD) to 248 µm-444 µm (Mean 382.85 ± 119.66 SD). Baseline BCVA improved from 0.4-1.0 logMAR (Mean 0.83 ± 0.22 SD) to 0.1-1.0 logMAR (Mean 0.45 ± 0.29 SD). We found a non-significant correlation between the percent reduction in CCT and the percent reduction in CMT as well as the percent improvement in BCVA over the entire study. However a statistically significant positive correlation was found between the percent reduction in CMT and the percent improvement in BCVA over the entire study.
Conclusion: IVI of Ranibizumab in the treatment of center involving diabetic macular edema results in reduction of the permeability of the choroidal blood vessels as well as the Sub-Foveal Choroidal Thickness (SFCT). However we could not establish a statistically significant correlation between the percent reduction in CCT, the percent reduction in CMT and the percent improvement in BCVA.
